Development of a High Throughput Screen for the Identification of Inhibitors of Peptidoglycan O-Acetyltransferases, New Potential Antibacterial Targets

The O-acetylation of peptidoglycan occurs in many Gram-negative and most Gram-positive pathogens and this modification to the essential wall polymer controls the lytic activity of the autolysins, particularly the lytic transglycosylases, and inhibits that of the lysozymes of innate immunity systems....

Descripción completa

Detalles Bibliográficos
Autores principales: Brott, Ashley S., Jones, Carys S., Clarke, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627197/
https://www.ncbi.nlm.nih.gov/pubmed/31137799
http://dx.doi.org/10.3390/antibiotics8020065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627197/
https://www.ncbi.nlm.nih.gov/pubmed/31137799
http://dx.doi.org/10.3390/antibiotics8020065

Ejemplares similares