Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms

The presence of an isocitrate dehydrogenase 1 (IDH1) mutation is associated with a less aggressive phenotype, increased sensitivity to radiation, and increased overall survival in patients with diffuse glioma. Based on in vitro experimentations in malignant glioma cell lines, the consequences on cel...

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Detalles Bibliográficos
Autores principales: Kessler, Jacqueline, Hohmann, Tim, Güttler, Antje, Petrenko, Marina, Ostheimer, Christian, Hohmann, Urszula, Bache, Matthias, Dehghani, Faramarz, Vordermark, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627228/
https://www.ncbi.nlm.nih.gov/pubmed/31242696
http://dx.doi.org/10.3390/cancers11060889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627228/
https://www.ncbi.nlm.nih.gov/pubmed/31242696
http://dx.doi.org/10.3390/cancers11060889

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