Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells

Lysine histone demethylases (KDMs) are considered potential therapeutic targets in several tumors, including glioblastoma (GB). In particular, KDM5A is involved in the acquisition of temozolomide (TMZ) resistance in adult GB cells and UDX/KDM6B regulates H3K27 methylation, which is involved in the p...

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Detalles Bibliográficos
Autores principales: Romani, Massimo, Daga, Antonio, Forlani, Alessandra, Pistillo, Maria Pia, Banelli, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627323/
https://www.ncbi.nlm.nih.gov/pubmed/31238504
http://dx.doi.org/10.3390/cancers11060878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627323/
https://www.ncbi.nlm.nih.gov/pubmed/31238504
http://dx.doi.org/10.3390/cancers11060878

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