Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes

Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity...

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Autores principales: Tauran, Yannick, Cerón-Carrasco, José Pedro, Rhimi, Moez, Perret, Florent, Kim, Beomjoon, Collard, Dominique, Coleman, Anthony W., Pérez-Sánchez, Horacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627454/
https://www.ncbi.nlm.nih.gov/pubmed/31163674
http://dx.doi.org/10.3390/antibiotics8020073
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author Tauran, Yannick
Cerón-Carrasco, José Pedro
Rhimi, Moez
Perret, Florent
Kim, Beomjoon
Collard, Dominique
Coleman, Anthony W.
Pérez-Sánchez, Horacio
author_facet Tauran, Yannick
Cerón-Carrasco, José Pedro
Rhimi, Moez
Perret, Florent
Kim, Beomjoon
Collard, Dominique
Coleman, Anthony W.
Pérez-Sánchez, Horacio
author_sort Tauran, Yannick
collection PubMed
description Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity, with para-sulfonato-calix[8]arene, SC8, having an IC(50) value of 6.4 μM. Molecular docking calculations show the SC8 can interact at both the polyanion binding site and also the catalytic site of H3N2 influenza PA endonuclease.
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spelling pubmed-66274542019-07-23 Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes Tauran, Yannick Cerón-Carrasco, José Pedro Rhimi, Moez Perret, Florent Kim, Beomjoon Collard, Dominique Coleman, Anthony W. Pérez-Sánchez, Horacio Antibiotics (Basel) Article Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity, with para-sulfonato-calix[8]arene, SC8, having an IC(50) value of 6.4 μM. Molecular docking calculations show the SC8 can interact at both the polyanion binding site and also the catalytic site of H3N2 influenza PA endonuclease. MDPI 2019-06-03 /pmc/articles/PMC6627454/ /pubmed/31163674 http://dx.doi.org/10.3390/antibiotics8020073 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tauran, Yannick
Cerón-Carrasco, José Pedro
Rhimi, Moez
Perret, Florent
Kim, Beomjoon
Collard, Dominique
Coleman, Anthony W.
Pérez-Sánchez, Horacio
Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title_full Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title_fullStr Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title_full_unstemmed Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title_short Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes
title_sort size and flexibility define the inhibition of the h3n2 influenza endonuclease enzyme by calix[n]arenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627454/
https://www.ncbi.nlm.nih.gov/pubmed/31163674
http://dx.doi.org/10.3390/antibiotics8020073
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