A Versatile Strategy to Reduce UGA-Selenocysteine Recoding Efficiency of the Ribosome Using CRISPR-Cas9-Viral-Like-Particles Targeting Selenocysteine-tRNA([Ser]Sec) Gene

The translation of selenoprotein mRNAs involves a non-canonical ribosomal event in which an in-frame UGA is recoded as a selenocysteine (Sec) codon instead of being read as a stop codon. The recoding machinery is centered around two dedicated RNA components: The selenocysteine insertion sequence (SE...

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Detalles Bibliográficos
Autores principales: Vindry, Caroline, Guillin, Olivia, Mangeot, Philippe E., Ohlmann, Théophile, Chavatte, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627462/
https://www.ncbi.nlm.nih.gov/pubmed/31212706
http://dx.doi.org/10.3390/cells8060574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627462/
https://www.ncbi.nlm.nih.gov/pubmed/31212706
http://dx.doi.org/10.3390/cells8060574

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