Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

[Image: see text] Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J., Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O., Henderson, Mark J., Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M., Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O., Shi, Wei Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627486/
https://www.ncbi.nlm.nih.gov/pubmed/31059257
http://dx.doi.org/10.1021/jacs.8b13506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627486/
https://www.ncbi.nlm.nih.gov/pubmed/31059257
http://dx.doi.org/10.1021/jacs.8b13506

Ejemplares similares