Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway

Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that induces proliferation and migration. Deregulation of FGFR2 contributes...

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Detalles Bibliográficos
Autores principales: Szybowska, Patrycja, Kostas, Michal, Wesche, Jørgen, Wiedlocha, Antoni, Haugsten, Ellen Margrethe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627556/
https://www.ncbi.nlm.nih.gov/pubmed/31146385
http://dx.doi.org/10.3390/cells8060518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627556/
https://www.ncbi.nlm.nih.gov/pubmed/31146385
http://dx.doi.org/10.3390/cells8060518

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