Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity

Excessive osteoclast differentiation and/or function plays a pivotal role in the pathogenesis of bone diseases such as osteoporosis and rheumatoid arthritis. Here, we examined whether fucoidan, a sulfated polysaccharide present in brown algae, attenuates receptor activator of nuclear factor-κB ligan...

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Detalles Bibliográficos
Autores principales: Lu, Sheng-Hua, Hsia, Yi-Jan, Shih, Kuang-Chung, Chou, Tz-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627629/
https://www.ncbi.nlm.nih.gov/pubmed/31185702
http://dx.doi.org/10.3390/md17060345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627629/
https://www.ncbi.nlm.nih.gov/pubmed/31185702
http://dx.doi.org/10.3390/md17060345

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