Cargando…

Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer

DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+ primary breast cancer cells, but the expression and subcellular localization of DUSPs, especially DUSP6, in HER2-positive circulating tumor ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Fan, McCuaig, Robert D., Sutton, Christopher R., Tan, Abel H. Y., Jeelall, Yoshni, Bean, Elaine G., Dai, Jin, Prasanna, Thiru, Batham, Jacob, Malik, Laeeq, Yip, Desmond, Dahlstrom, Jane E., Rao, Sudha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627630/ https://www.ncbi.nlm.nih.gov/pubmed/31238530 http://dx.doi.org/10.3390/ijms20123080

Ejemplares similares

Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer
por: Boulding, Tara, et al.
Publicado: (2016)

A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED)
por: Prasanna, Thiru, et al.
Publicado: (2022)

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch
por: Tu, Wen Juan, et al.
Publicado: (2020)

Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy
por: Prasanna, Thiru, et al.
Publicado: (2018)

Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8(+) T Cells in Immunotherapy-Resistant and Metastatic Cancers
por: Dunn, Jenny, et al.
Publicado: (2022)

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer
por: Tan, Abel H. Y., et al.
Publicado: (2019)

Identification of chromatin accessibility domains in human breast cancer stem cells
por: Hardy, K., et al.
Publicado: (2016)

Pelvic congestion syndrome
por: Robertson, Meiri, et al.
Publicado: (2015)

Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics
por: McCuaig, Bonita, et al.
Publicado: (2023)

Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes
por: Dunn, Jennifer, et al.
Publicado: (2015)

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
por: Boulding, T., et al.
Publicado: (2018)

Author Correction: LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
por: Boulding, T., et al.
Publicado: (2019)

SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
por: Batham, Jacob, et al.
Publicado: (2019)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

Nurse Practitioners in Orthopaedic Surgical Settings: A Review of the Literature
por: Spence, Brittany G., et al.
Publicado: (2019)

The bivalve Thyasira cf. gouldi hosts chemoautotrophic symbiont populations with strain level diversity
por: McCuaig, Bonita, et al.
Publicado: (2017)

Methodological challenges in the comparison of infant fMRI across age groups
por: Cusack, Rhodri, et al.
Publicado: (2017)

Vulvar involvement in epidermolysis bullosa: Case series
por: Dang, Julie, et al.
Publicado: (2021)

Exploring a Complementary Stress Management and Wellbeing Intervention Model for Teachers: Participant Experience
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

The Relationship between Mindful Attention Awareness, Perceived Stress and Subjective Wellbeing
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

Fathers’ Experiences and Perspectives of Breastfeeding: A Scoping Review
por: Sihota, Harvinder, et al.
Publicado: (2019)

Metagenomic analysis suggests broad metabolic potential in extracellular symbionts of the bivalve Thyasira cf. gouldi
por: McCuaig, Bonita, et al.
Publicado: (2020)

A Complementary Intervention to Promote Wellbeing and Stress Management for Early Career Teachers
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

Extramedullary hematopoiesis secondary to COVID-19: A first case report in a newborn
por: Caudrelier, Nicolas, et al.
Publicado: (2022)

DUSPs, to MAP kinases and beyond
por: Huang, Ching-Yu, et al.
Publicado: (2012)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation
por: McCuaig, Robert Duncan, et al.
Publicado: (2015)

Sexual Health in Men With Traumatic Spinal Cord Injuries: A Review and Recommendations for Primary Health-Care Providers
por: Aikman, Kirsten, et al.
Publicado: (2018)

Eating Disorders in Males: How Primary Care Providers Can Improve Recognition, Diagnosis, and Treatment
por: Sangha, Simrin, et al.
Publicado: (2019)

DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway
por: Bai, Huimin, et al.
Publicado: (2021)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms
por: McCuaig, Kimberly, et al.
Publicado: (1993)

Psychosocial Interventions for Women with a BRCA1 or BRCA2 Mutation: A Scoping Review
por: Boghosian, Talin, et al.
Publicado: (2021)

Next-Generation Service Delivery: A Scoping Review of Patient Outcomes Associated with Alternative Models of Genetic Counseling and Genetic Testing for Hereditary Cancer
por: McCuaig, Jeanna M., et al.
Publicado: (2018)

DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer
por: Teng, Fei, et al.
Publicado: (2018)

DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer
por: Shen, Jiliang, et al.
Publicado: (2017)

A National Needs Assessment of Canadian Nurse Practitioners Regarding Cannabis for Therapeutic Purposes
por: Balneaves, Lynda G., et al.
Publicado: (2018)

Isotretinoin for the treatment of severe acneiform eruptions associated with the MEK inhibitor trametinib
por: Caruana, Marco, et al.
Publicado: (2020)

Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells
por: Tu, Wen Juan, et al.
Publicado: (2017)

Using Google Ads to recruit and retain a cohort considering abortion in the United States()()
por: Upadhyay, Ushma D., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_75au83j5uk9mcuce86tsv2f4q8