Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes

Sirt1 (Sirtuin 1), AMPK (AMP-activated protein kinase), and eNOS (endothelial nitric oxide synthase) modulate hepatic energy metabolism and inflammation and play a major role in the development of NASH. Cyclic nucleotide phosphodiesterases (PDEs) play an important role in signal transduction by modu...

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Detalles Bibliográficos
Autores principales: Banerjee, Jheelam, Bruckbauer, Antje, Thorpe, Teresa, Zemel, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627652/
https://www.ncbi.nlm.nih.gov/pubmed/31248114
http://dx.doi.org/10.3390/ijms20122992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627652/
https://www.ncbi.nlm.nih.gov/pubmed/31248114
http://dx.doi.org/10.3390/ijms20122992

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