Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is known to symmetrically dimethylate numerous cytosolic and nuclear proteins that are involved in a variety of cellular processes. Recent findings have revealed its potential as a cancer therapeutic target. PRMT5 possesses a cysteine (C...

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Detalles Bibliográficos
Autores principales: Lin, Hong, Wang, Min, Zhang, Yang W., Tong, Shuilong, Leal, Raul A., Shetty, Rupa, Vaddi, Kris, Luengo, Juan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627734/
https://www.ncbi.nlm.nih.gov/pubmed/31312404
http://dx.doi.org/10.1021/acsmedchemlett.9b00074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627734/
https://www.ncbi.nlm.nih.gov/pubmed/31312404
http://dx.doi.org/10.1021/acsmedchemlett.9b00074

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