Cargando…

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is known to symmetrically dimethylate numerous cytosolic and nuclear proteins that are involved in a variety of cellular processes. Recent findings have revealed its potential as a cancer therapeutic target. PRMT5 possesses a cysteine (C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Hong, Wang, Min, Zhang, Yang W., Tong, Shuilong, Leal, Raul A., Shetty, Rupa, Vaddi, Kris, Luengo, Juan I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627734/ https://www.ncbi.nlm.nih.gov/pubmed/31312404 http://dx.doi.org/10.1021/acsmedchemlett.9b00074

Ejemplares similares

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
por: Shailesh, Harshita, et al.
Publicado: (2018)

Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells
por: Rasheed, Shayaan, et al.
Publicado: (2023)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine
por: Hernandez, Juan E, et al.
Publicado: (2023)

Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review
por: Feustel, Kavanya, et al.
Publicado: (2022)

KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5
por: di Caprio, Roberta, et al.
Publicado: (2015)

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
por: Liu, Min, et al.
Publicado: (2019)

Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma
por: Sloan, Shelby L., et al.
Publicado: (2021)

Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
por: Al-Hamashi, Ayad A., et al.
Publicado: (2021)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2015)

The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4
por: Mallappa, Chandrashekara, et al.
Publicado: (2011)

Structure and Function of Protein Arginine Methyltransferase PRMT7
por: Halabelian, Levon, et al.
Publicado: (2021)

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome
por: Hernando, Carlos E, et al.
Publicado: (2015)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes
por: Rehman, Ishita, et al.
Publicado: (2018)

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
por: Ho, Meng-Chiao, et al.
Publicado: (2013)

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
por: Ma, Dapeng, et al.
Publicado: (2021)

Protein Arginine Methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in Multiple Myeloma
por: Gullà, Annamaria, et al.
Publicado: (2017)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
por: Dong, Rui, et al.
Publicado: (2021)

Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
por: Cura, Vincent, et al.
Publicado: (2021)

Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis
por: Yang, Mei, et al.
Publicado: (2009)

Correction: Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
por: Ho, Meng-Chiao, et al.
Publicado: (2013)

Arginine methyltransferases PRMT2 and PRMT3 are essential for biosynthesis of plant-polysaccharide-degrading enzymes in Penicillium oxalicum
por: Zhao, Shuai, et al.
Publicado: (2023)

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells
por: Li, Mingyue, et al.
Publicado: (2019)

The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
por: Bai, Xuemei, et al.
Publicado: (2022)

Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
por: Lin, Chang-Ching, et al.
Publicado: (2023)

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification
por: Ito, Tatsuo, et al.
Publicado: (2009)

PRMT7: A Pivotal Arginine Methyltransferase in Stem Cells and Development
por: Wang, Bingyuan, et al.
Publicado: (2021)

The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors in Caenorhabditis elegans
por: Bowitch, Alexander, et al.
Publicado: (2018)

Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach
por: Vlummens, Philip, et al.
Publicado: (2022)

The Methyltransferases PRMT4/CARM1 and PRMT5 Control Differentially Myogenesis in Zebrafish
por: Batut, Julie, et al.
Publicado: (2011)

Cell Cycle Regulation by the PRMT6 Arginine Methyltransferase through Repression of Cyclin-Dependent Kinase Inhibitors
por: Kleinschmidt, Markus A., et al.
Publicado: (2012)

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy
por: Tang, Yixuan, et al.
Publicado: (2022)

Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues
por: Jia, Zhihao, et al.
Publicado: (2020)

The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility
por: Azhar, Muhammad, et al.
Publicado: (2023)

The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation
por: Kleinschmidt, Markus A., et al.
Publicado: (2008)

The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer
por: Choucair, Ali, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l1ls6ue3iqt4j1n18m4h2dmdvb