A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

We previously synthesized an hydroxamate derivative (N-hydroxy-4-[2-(3-methoxyphenyl)acetamido]benzamide) named 363 with potent anti-Toxoplasma gondii activity and histone deacetylase inhibitor (HDACi) effects. Here we show that 1-N-hydroxy-4-N-[(2-methoxyphenyl)methyl]benzene-1,4-dicarboxamide, a 3...

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Detalles Bibliográficos
Autores principales: Loeuillet, Corinne, Touquet, Bastien, Guichou, Jean François, Labesse, Gilles, Sereno, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627744/
https://www.ncbi.nlm.nih.gov/pubmed/31216674
http://dx.doi.org/10.3390/ijms20122973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627744/
https://www.ncbi.nlm.nih.gov/pubmed/31216674
http://dx.doi.org/10.3390/ijms20122973

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