Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

Inhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung and cervical cancer. As torsional stress is generated during transcription by progression of RNA polymerase II thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Riedlinger, Tabea, Bartkuhn, Marek, Zimmermann, Tobias, Hake, Sandra B., Nist, Andrea, Stiewe, Thorsten, Kracht, Michael, Schmitz, M. Lienhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627772/
https://www.ncbi.nlm.nih.gov/pubmed/31242600
http://dx.doi.org/10.3390/cancers11060883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627772/
https://www.ncbi.nlm.nih.gov/pubmed/31242600
http://dx.doi.org/10.3390/cancers11060883

Ejemplares similares