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Nucleolar and Ribosomal Dysfunction—A Common Pathomechanism in Childhood Progerias?
The nucleolus organizes around the sites of transcription by RNA polymerase I (RNA Pol I). rDNA transcription by this enzyme is the key step of ribosome biogenesis and most of the assembly and maturation processes of the ribosome occur co-transcriptionally. Therefore, disturbances in rRNA transcript...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627804/ https://www.ncbi.nlm.nih.gov/pubmed/31167386 http://dx.doi.org/10.3390/cells8060534 |