Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans

Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to induce neutrophil extracellular traps (NETs), whic...

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Detalles Bibliográficos
Autores principales: Mergaert, Aisha M., Bawadekar, Mandar, Nguyen, Thai Q., Massarenti, Laura, Holmes, Caitlyn L., Rebernick, Ryan, Schrodi, Steven J., Shelef, Miriam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627847/
https://www.ncbi.nlm.nih.gov/pubmed/31242568
http://dx.doi.org/10.3390/ijms20123093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627847/
https://www.ncbi.nlm.nih.gov/pubmed/31242568
http://dx.doi.org/10.3390/ijms20123093

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