Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase

The cupin-type phosphoglucose isomerase (PfPGI) from the hyperthermophilic archaeon Pyrococcus furiosus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. We investigated PfPGI using protein-engineering bioinformatics tools to select functionally-important residue...

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Detalles Bibliográficos
Autores principales: Subramanian, Kalyanasundaram, Mitusińska, Karolina, Raedts, John, Almourfi, Feras, Joosten, Henk-Jan, Hendriks, Sjon, Sedelnikova, Svetlana E., Kengen, Servé W. M., Hagen, Wilfred R., Góra, Artur, Martins dos Santos, Vitor A. P., Baker, Patrick J., van der Oost, John, Schaap, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627849/
https://www.ncbi.nlm.nih.gov/pubmed/31159273
http://dx.doi.org/10.3390/biom9060212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627849/
https://www.ncbi.nlm.nih.gov/pubmed/31159273
http://dx.doi.org/10.3390/biom9060212

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