Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors

Cholesterol is a pivotal factor for cancer cells to entertain their relentless growth. In this case, we provide a novel strategy to inhibit tumor growth by simultaneous activation of liver-X-receptors and interference with Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1). Informed by a tr...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Bianchetti, Elena, Karpel-Massler, Georg, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627953/
https://www.ncbi.nlm.nih.gov/pubmed/31181660
http://dx.doi.org/10.3390/cancers11060788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627953/
https://www.ncbi.nlm.nih.gov/pubmed/31181660
http://dx.doi.org/10.3390/cancers11060788

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