Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Aim: Primary human hepatocytes (PHHs) undergo dedifferentiation upon the two-dimensional (2D) culture, which particularly hinders their utility in long-term in vitro studies. Lipids, as a major class of biomolecules, play crucial roles in cellular energy storage, structure, and signaling. Here, for...

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Detalles Bibliográficos
Autores principales: Kiamehr, Mostafa, Heiskanen, Laura, Laufer, Thomas, Düsterloh, Aneta, Kahraman, Mustafa, Käkelä, Reijo, Laaksonen, Reijo, Aalto-Setälä, Katriina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627955/
https://www.ncbi.nlm.nih.gov/pubmed/31207892
http://dx.doi.org/10.3390/ijms20122910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627955/
https://www.ncbi.nlm.nih.gov/pubmed/31207892
http://dx.doi.org/10.3390/ijms20122910

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