Cargando…

Comprehensive Profiling of Primary and Metastatic ccRCC Reveals a High Homology of the Metastases to a Subregion of the Primary Tumour

While intratumour genetic heterogeneity of primary clear cell renal cell carcinoma (ccRCC) is well characterized, the genomic profiles of metastatic ccRCCs are seldom studied. We profiled the genomes and transcriptomes of a primary tumour and matched metastases to better understand the evolutionary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferronika, Paranita, Hof, Joost, Kats-Ugurlu, Gursah, Sijmons, Rolf H., Terpstra, Martijn M., de Lange, Kim, Leliveld-Kors, Annemarie, Westers, Helga, Kok, Klaas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628027/ https://www.ncbi.nlm.nih.gov/pubmed/31212796 http://dx.doi.org/10.3390/cancers11060812

Ejemplares similares

Untangling ccRCC prognosis with SLINKY
por: Reinfeld, Bradley I., et al.
Publicado: (2017)

Functional and translational consequences of immunometabolic coevolution in ccRCC
por: Reznik, Ed, et al.
Publicado: (2023)

CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9
por: Du, Tan, et al.
Publicado: (2023)

Pivotal biomarker expression and drug screening in advanced ccRCC
por: Xiao, Wen, et al.
Publicado: (2020)

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting Glycolysis
por: Fang, Zhiyu, et al.
Publicado: (2021)

Identification of key genes of the ccRCC subtype with poor prognosis
por: Puzanov, Grigory Andreevich
Publicado: (2022)

MT1X is an oncogene and indicates prognosis in ccRCC
por: Ding, Yanpeng, et al.
Publicado: (2022)

Cuproptosis in ccRCC: key player in therapeutic and prognostic targets
por: Lv, Yang, et al.
Publicado: (2023)

Thioredoxin 1 (Trx1) is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC): an example for the crucial role of redox signaling in ccRCC
por: Ribback, Silvia, et al.
Publicado: (2021)

Does the Urinary Proteome Reflect ccRCC Stage and Grade Progression?
por: Santorelli, Lucia, et al.
Publicado: (2021)

A multiomics disease progression signature of low-risk ccRCC
por: Strauss, Philipp, et al.
Publicado: (2022)

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC
por: Xue, Wei, et al.
Publicado: (2023)

Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database
por: Wan, Bangbei, et al.
Publicado: (2020)

Bioinformatics Analysis of Prognostic Value of SPC24 in ccRCC and Pan-Cancer
por: Zhang, Jipeng, et al.
Publicado: (2022)

Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC
por: Huang, Ruizhen, et al.
Publicado: (2022)

Identification of AKI signatures and classification patterns in ccRCC based on machine learning
por: Wang, Li, et al.
Publicado: (2023)

Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics
por: Oliveira, Rita de Cássia, et al.
Publicado: (2017)

Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients
por: Qin, Shijie, et al.
Publicado: (2019)

In-Depth Mapping of the Urinary N-Glycoproteome: Distinct Signatures of ccRCC-related Progression
por: Santorelli, Lucia, et al.
Publicado: (2020)

LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway
por: Hong, Quan, et al.
Publicado: (2020)

CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates
por: Lv, Zheng, et al.
Publicado: (2021)

SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC
por: Ganner, Athina, et al.
Publicado: (2023)

Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma
por: van de Pol, Jeroen A. A., et al.
Publicado: (2022)

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors
por: Wrzesiński, Tomasz, et al.
Publicado: (2015)

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
por: Du, Weinan, et al.
Publicado: (2017)

Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC
por: Qian, Siwei, et al.
Publicado: (2020)

Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
por: Reustle, Anna, et al.
Publicado: (2020)

Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients
por: Meng, Yiliang, et al.
Publicado: (2021)

PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability
por: Chen, Siming, et al.
Publicado: (2021)

The Hippo pathway effector YAP inhibits HIF2 signaling and ccRCC tumor growth
por: Li, Xu, et al.
Publicado: (2022)

Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing
por: Charbonneau, Martine, et al.
Publicado: (2022)

Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC
por: Li, Lingqin, et al.
Publicado: (2023)

Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in  Clear - Cell Renal Cell Carcinoma (ccRCC)
por: Bielecka, Zofia F., et al.
Publicado: (2013)

Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC
por: Ma, Jing, et al.
Publicado: (2020)

Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC)
por: Zhengqi, Qiu, et al.
Publicado: (2021)

CD103+ Tissue Resident T-Lymphocytes Accumulate in Lung Metastases and Are Correlated with Poor Prognosis in ccRCC
por: Sanders, Christine, et al.
Publicado: (2022)

PLK4 Is a Potential Biomarker for Abnormal Tumor Proliferation, Immune Infiltration, and Prognosis in ccRCC
por: Hu, Chenglu, et al.
Publicado: (2022)

Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCC
por: Langbein, Lauren E., et al.
Publicado: (2022)

Role of copper ionophore–induced death in immune microenvironment and clinical prognosis of ccRCC: An integrated analysis
por: Xia, Shunyao, et al.
Publicado: (2022)

Defining candidate mRNA and protein EV biomarkers to discriminate ccRCC and pRCC from non-malignant renal cells in vitro
por: Zieren, Richard C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_80b321bpigj4j0fi2bndgndv92