Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or CYSLTR2 genes. Direct inhibition of constitutively active oncoproteins deriving from these mutations is still in its infancy in UM,...

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Detalles Bibliográficos
Autores principales: Croce, Michela, Ferrini, Silvano, Pfeffer, Ulrich, Gangemi, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628160/
https://www.ncbi.nlm.nih.gov/pubmed/31216772
http://dx.doi.org/10.3390/cancers11060846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628160/
https://www.ncbi.nlm.nih.gov/pubmed/31216772
http://dx.doi.org/10.3390/cancers11060846

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