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Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells

Bone morphogenetic protein (BMP) and Notch signaling are critical for endothelial cell (EC) differentiation in vascular development. Recent studies have shown that excess BMP activity induces Notch signaling in cerebral ECs resulting in arteriovenous malformation (AVMs). However, it is unclear how t...

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Detalles Bibliográficos
Autores principales: Wu, Xiuju, Yao, Jiayi, Wang, Lumin, Zhang, Daoqin, Zhang, Li, Reynolds, Eric X., Yu, Tongtong, Boström, Kristina I., Yao, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628192/
https://www.ncbi.nlm.nih.gov/pubmed/31174355
http://dx.doi.org/10.3390/cells8060549