Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA(2)-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom

MiDCA1, a phospholipase A(2) (PLA(2)) neurotoxin isolated from Micrurus dumerilii carinicauda coral snake venom, inhibited a major component of voltage-activated potassium (Kv) currents (41 ± 3% inhibition with 1 μM toxin) in mouse cultured dorsal root ganglion (DRG) neurons. In addition, the select...

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Detalles Bibliográficos
Autores principales: Schütter, Niklas, Barreto, Yuri Correia, Vardanyan, Vitya, Hornig, Sönke, Hyslop, Stephen, Marangoni, Sérgio, Rodrigues-Simioni, Léa, Pongs, Olaf, Dal Belo, Cháriston André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628393/
https://www.ncbi.nlm.nih.gov/pubmed/31212818
http://dx.doi.org/10.3390/toxins11060335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628393/
https://www.ncbi.nlm.nih.gov/pubmed/31212818
http://dx.doi.org/10.3390/toxins11060335

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