Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging, mostly for obtaining appropriate folding and con...

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Detalles Bibliográficos
Autores principales: Nicolas, Sébastien, Zoukimian, Claude, Bosmans, Frank, Montnach, Jérôme, Diochot, Sylvie, Cuypers, Eva, De Waard, Stephan, Béroud, Rémy, Mebs, Dietrich, Craik, David, Boturyn, Didier, Lazdunski, Michel, Tytgat, Jan, De Waard, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628435/
https://www.ncbi.nlm.nih.gov/pubmed/31234412
http://dx.doi.org/10.3390/toxins11060367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628435/
https://www.ncbi.nlm.nih.gov/pubmed/31234412
http://dx.doi.org/10.3390/toxins11060367

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