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The role of gelsolin domain 3 in familial amyloidosis (Finnish type)
In the disease familial amyloidosis, Finnish type (FAF), also known as AGel amyloidosis (AGel), the mechanism by which point mutations in the calcium-regulated actin-severing protein gelsolin lead to furin cleavage is not understood in the intact protein. Here, we provide a structural and biochemica...
Autores principales: | Zorgati, Habiba, Larsson, Mårten, Ren, Weitong, Sim, Adelene Y. L., Gettemans, Jan, Grimes, Jonathan M., Li, Wenfei, Robinson, Robert C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628662/ https://www.ncbi.nlm.nih.gov/pubmed/31243148 http://dx.doi.org/10.1073/pnas.1902189116 |
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