Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

The cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase (PKG) was identified >25 y ago; however, efforts to obtain a structure of the entire PKG enzyme or catalytic domain from any species have failed. In malaria parasites, cooperative activation of PKG triggers crucial developme...

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Detalles Bibliográficos
Autores principales: El Bakkouri, Majida, Kouidmi, Imène, Wernimont, Amy K., Amani, Mehrnaz, Hutchinson, Ashley, Loppnau, Peter, Kim, Jeong Joo, Flueck, Christian, Walker, John R., Seitova, Alma, Senisterra, Guillermo, Kakihara, Yoshito, Kim, Choel, Blackman, Michael J., Calmettes, Charles, Baker, David A., Hui, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628679/
https://www.ncbi.nlm.nih.gov/pubmed/31239348
http://dx.doi.org/10.1073/pnas.1905558116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628679/
https://www.ncbi.nlm.nih.gov/pubmed/31239348
http://dx.doi.org/10.1073/pnas.1905558116

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