A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we probed the role of glutathione transferase (...

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Detalles Bibliográficos
Autores principales: De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628828/
https://www.ncbi.nlm.nih.gov/pubmed/31221747
http://dx.doi.org/10.1073/pnas.1903297116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628828/
https://www.ncbi.nlm.nih.gov/pubmed/31221747
http://dx.doi.org/10.1073/pnas.1903297116

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