Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA crosslink

Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. HMCES recognizes and processes these lesions in the context of single-stranded DNA (ssDNA). A HMCES DNA-protein crosslink (DPC) intermediate is thought to shield the AP site from endonucleases and error-pron...

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Detalles Bibliográficos
Autores principales: Thompson, Petria S., Amidon, Katherine M., Mohni, Kareem N., Cortez, David, Eichman, Brandt F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628887/
https://www.ncbi.nlm.nih.gov/pubmed/31235915
http://dx.doi.org/10.1038/s41594-019-0255-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628887/
https://www.ncbi.nlm.nih.gov/pubmed/31235915
http://dx.doi.org/10.1038/s41594-019-0255-5

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