Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing the mitochondrial oxidative respiration rate. Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending the lifespan of...

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Detalles Bibliográficos
Autores principales: Su, Yuan, Wang, Tao, Wu, Nan, Li, Diyan, Fan, Xiaolan, Xu, Zhongxian, Mishra, Shailendra Kumar, Yang, Mingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
https://www.ncbi.nlm.nih.gov/pubmed/31242135
http://dx.doi.org/10.18632/aging.102045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
https://www.ncbi.nlm.nih.gov/pubmed/31242135
http://dx.doi.org/10.18632/aging.102045

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