SCN5A mutation G615E results in Na(V)1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

SCN5A is expressed in cardiomyocytes and gastrointestinal (GI) smooth muscle cells (SMCs) as the voltage-gated mechanosensitive sodium channel Na(V)1.5. The influx of Na(+) through Na(V)1.5 produces a fast depolarization in membrane potential, indispensable for electrical excitability in cardiomyocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Strege, Peter R., Mercado-Perez, Arnaldo, Mazzone, Amelia, Saito, Yuri A., Bernard, Cheryl E., Farrugia, Gianrico, Beyder, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629189/
https://www.ncbi.nlm.nih.gov/pubmed/31262209
http://dx.doi.org/10.1080/19336950.2019.1632670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629189/
https://www.ncbi.nlm.nih.gov/pubmed/31262209
http://dx.doi.org/10.1080/19336950.2019.1632670

Ejemplares similares