Cargando…

SCN5A mutation G615E results in Na(V)1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

SCN5A is expressed in cardiomyocytes and gastrointestinal (GI) smooth muscle cells (SMCs) as the voltage-gated mechanosensitive sodium channel Na(V)1.5. The influx of Na(+) through Na(V)1.5 produces a fast depolarization in membrane potential, indispensable for electrical excitability in cardiomyocy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strege, Peter R., Mercado-Perez, Arnaldo, Mazzone, Amelia, Saito, Yuri A., Bernard, Cheryl E., Farrugia, Gianrico, Beyder, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629189/ https://www.ncbi.nlm.nih.gov/pubmed/31262209 http://dx.doi.org/10.1080/19336950.2019.1632670

Ejemplares similares

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
por: Strege, Peter R, et al.
Publicado: (2023)

Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity
por: Beyder, Arthur, et al.
Publicado: (2012)

Capsaicin as an amphipathic modulator of Na(V)1.5 mechanosensitivity
por: Cowan, Luke M., et al.
Publicado: (2022)

Voltage gating of mechanosensitive PIEZO channels
por: Moroni, Mirko, et al.
Publicado: (2018)

Voltage-Gated Channel Mechanosensitivity: Fact or Friction?
por: Morris, Catherine E.
Publicado: (2011)

Commentary: Voltage Gating of Mechanosensitive PIEZO Channels
por: Kaestner, Lars, et al.
Publicado: (2018)

Ranolazine inhibits shear sensitivity of endogenous Na(+) current and spontaneous action potentials in HL-1 cells
por: Strege, Peter, et al.
Publicado: (2012)

Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels
por: Baker, Mark D., et al.
Publicado: (2020)

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
por: Alcaino, Constanza, et al.
Publicado: (2018)

Life Cycle of the Cardiac Voltage-Gated Sodium Channel Na(V)1.5
por: Dong, Caijuan, et al.
Publicado: (2020)

Characterization of maturation of neuronal voltage-gated sodium channels SCN1A and SCN8A in rat myocardium
por: Krause, Ulrich, et al.
Publicado: (2015)

Voltage-dependent gating of veratridine-modified Na channels
Publicado: (1986)

microRNA overexpression in slow transit constipation leads to reduced Na(V)1.5 current and altered smooth muscle contractility
por: Mazzone, Amelia, et al.
Publicado: (2020)

The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons
por: Ravenscroft, Thomas A., et al.
Publicado: (2023)

Calmodulin and Ca(2+) control of voltage gated Na(+) channels
por: Gabelli, Sandra B, et al.
Publicado: (2015)

Differential Sialylation Modulates Voltage-gated Na(+) Channel Gating throughout the Developing Myocardium
por: Stocker, Patrick J., et al.
Publicado: (2006)

The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1999)

Coupling between Voltage Sensors and Activation Gate in Voltage-gated K(+) Channels
por: Lu, Zhe, et al.
Publicado: (2002)

Sodium channel Na(V)1.3 is important for enterochromaffin cell excitability and serotonin release
por: Strege, Peter R., et al.
Publicado: (2017)

In Pursuit of the Epithelial Mechanosensitivity Mechanisms
por: Beyder, Arthur
Publicado: (2019)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Lysine and the Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels
por: Li, Yang, et al.
Publicado: (2016)

Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
por: Rhana, P., et al.
Publicado: (2017)

Voltage-gated Na(+) currents in human dorsal root ganglion neurons
por: Zhang, Xiulin, et al.
Publicado: (2017)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

A mechanistic reinterpretation of fast inactivation in voltage-gated Na(+) channels
por: Liu, Yichen, et al.
Publicado: (2023)

Structure and electromechanical coupling of a voltage-gated Na(+)/H(+) exchanger
por: Yeo, Hyunku, et al.
Publicado: (2023)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins
por: Osorio-Méndez, Daniel, et al.
Publicado: (2022)

Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1998)

Molecular mechanism of voltage sensing in voltage-gated proton channels
por: Gonzalez, Carlos, et al.
Publicado: (2013)

Mechanism of voltage gating in the voltage-sensing phosphatase Ci-VSP
por: Shen, Rong, et al.
Publicado: (2022)

Role of Transmembrane Segment S5 on Gating of Voltage-dependent K(+) Channels
por: Shieh, Char-Chang, et al.
Publicado: (1997)

Hysteresis in voltage-gated channels
por: Villalba-Galea, Carlos A.
Publicado: (2016)

Development of high-affinity nanobodies specific for Na(V)1.4 and Na(V)1.5 voltage-gated sodium channel isoforms
por: Srinivasan, Lakshmi, et al.
Publicado: (2022)

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na(v)1.7 and Na(v)1.5
por: Bok, Chan-Su, et al.
Publicado: (2023)

Regulatory Role of Voltage-Gated Na(+) Channel β Subunits in Sensory Neurons
por: Chahine, Mohamed, et al.
Publicado: (2011)

Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes
por: Caves, Rachel E., et al.
Publicado: (2020)

Agonist-specific voltage-dependent gating of lysosomal two-pore Na(+) channels
por: Zhang, Xiaoli, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_o7uf3au2plduabv4l35dk8bmhl