Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine recep...

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Detalles Bibliográficos
Autores principales: Yoshida, Yukihiro, Fujigaki, Hidetsugu, Kato, Koichi, Yamazaki, Kyoka, Fujigaki, Suwako, Kunisawa, Kazuo, Yamamoto, Yasuko, Mouri, Akihiro, Oda, Akifumi, Nabeshima, Toshitaka, Saito, Kuniaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629613/
https://www.ncbi.nlm.nih.gov/pubmed/31308447
http://dx.doi.org/10.1038/s41598-019-46666-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629613/
https://www.ncbi.nlm.nih.gov/pubmed/31308447
http://dx.doi.org/10.1038/s41598-019-46666-y

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