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Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse
The visceral endoderm is a polarized epithelial monolayer necessary for early embryonic development in rodents. A key feature of this epithelium is an active endocytosis and degradation of maternal nutrients, in addition to being the source of various signaling molecules or inhibitors required for t...
Autores principales: | Perea-Gomez, Aitana, Cases, Olivier, Lelièvre, Vincent, Pulina, Maria V., Collignon, Jérôme, Hadjantonakis, Anna-Katerina, Kozyraki, Renata |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629654/ https://www.ncbi.nlm.nih.gov/pubmed/31308417 http://dx.doi.org/10.1038/s41598-019-46559-0 |
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