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The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer

In cancer, cellular senescence is a complex process that leads to inhibition of proliferation of cells that may develop a neoplastic phenotype. A plethora of signaling pathways, when dysregulated, have been shown to elicit a senescence response. Two well-known tumor suppressor pathways, controlled b...

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Detalles Bibliográficos
Autores principales: Sossey-Alaoui, Khalid, Pluskota, Elzbieta, Szpak, Dorota, Plow, Edward F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629707/
https://www.ncbi.nlm.nih.gov/pubmed/31308359
http://dx.doi.org/10.1038/s41419-019-1774-z