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Activation of Cortical Somatostatin Interneurons Rescues Synapse Loss and Motor Deficits after Acute MPTP Infusion

Adult dendritic spines present structural and functional plasticity, which forms the basis of learning and memory. To provide in vivo evidence of spine plasticity under neurotoxicity, we generated an acute motor deficit model by single injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...

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Detalles Bibliográficos
Autores principales: Chen, Kai, Yang, Guang, So, Kwok-Fai, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629723/
https://www.ncbi.nlm.nih.gov/pubmed/31307003
http://dx.doi.org/10.1016/j.isci.2019.06.040