Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New K(V)3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide

There is increasing evidence that the fast-inactivating potassium current I(A), encoded by K(V)3. 4 channels, plays an important role in Alzheimer's Disease (AD), since the neurotoxic β-amyloid peptide1-42 (Aβ(1−42)) increases the I(A) current triggering apoptotic processes. The specific inhibi...

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Detalles Bibliográficos
Autores principales: Ciccone, Roselia, Piccialli, Ilaria, Grieco, Paolo, Merlino, Francesco, Annunziato, Lucio, Pannaccione, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629785/
https://www.ncbi.nlm.nih.gov/pubmed/31338361
http://dx.doi.org/10.3389/fchem.2019.00479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629785/
https://www.ncbi.nlm.nih.gov/pubmed/31338361
http://dx.doi.org/10.3389/fchem.2019.00479

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