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Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New K(V)3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide
There is increasing evidence that the fast-inactivating potassium current I(A), encoded by K(V)3. 4 channels, plays an important role in Alzheimer's Disease (AD), since the neurotoxic β-amyloid peptide1-42 (Aβ(1−42)) increases the I(A) current triggering apoptotic processes. The specific inhibi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629785/ https://www.ncbi.nlm.nih.gov/pubmed/31338361 http://dx.doi.org/10.3389/fchem.2019.00479 |