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Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains

The inter-cellular propagation of tau aggregates in several neurodegenerative diseases involves, in part, recurring cycles of extracellular tau uptake, initiation of endogenous tau aggregation, and extracellular release of at least part of this protein complex. However, human brain tau extracts from...

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Detalles Bibliográficos
Autores principales: Karikari, Thomas K., Nagel, David A., Grainger, Alastair, Clarke-Bland, Charlotte, Crowe, James, Hill, Eric J., Moffat, Kevin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629824/
https://www.ncbi.nlm.nih.gov/pubmed/31338022
http://dx.doi.org/10.3389/fncel.2019.00296