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Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

BACKGROUND: Exogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents. In this regard, the role of endogenous IGF-1 in brain responses to brain insults like excitotoxicity, a common patholog...

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Detalles Bibliográficos
Autores principales: Chen, Wei, He, Bin, Tong, Wusong, Zeng, Jinsong, Zheng, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629877/
https://www.ncbi.nlm.nih.gov/pubmed/31338023
http://dx.doi.org/10.3389/fncel.2019.00298