Cargando…
Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells
Herein, ruthenium complexes containing heterocyclic thioamidates [Ru(mmi)(bipy)(dppb)]PF(6) (1), [Ru(tzdt)(bipy)(dppb)]PF(6) (2), [Ru(dmp)(bipy)(dppb)]PF(6) (3) and [Ru(mpca)(bipy)(dppb)]PF(6) (4) were investigated for their cellular and molecular effects in cancer cell lines. Complexes 1 and 2 were...
Autores principales: | Neves, Sara P., de Carvalho, Nanashara C., da Silva, Monize M., Rodrigues, Ana Carolina B. C., Bomfim, Larissa M., Dias, Rosane B., Sales, Caroline B. S., Rocha, Clarissa A. Gurgel, Soares, Milena B. P., Batista, Alzir A., Bezerra, Daniel P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629894/ https://www.ncbi.nlm.nih.gov/pubmed/31338323 http://dx.doi.org/10.3389/fonc.2019.00562 |
Ejemplares similares
-
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells
por: Bomfim, Larissa M., et al.
Publicado: (2019) -
Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model
por: Baliza, Ingrid R. S., et al.
Publicado: (2019) -
Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling
por: Silva, Suellen L. R., et al.
Publicado: (2019) -
A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway
por: de Carvalho, Nanashara C., et al.
Publicado: (2018) -
Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells
por: D’Sousa Costa, Cinara O., et al.
Publicado: (2017)