Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application

Ex vivo retroviral gene transfer into CD34(+) hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve r...

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Detalles Bibliográficos
Autores principales: Schott, Juliane W., León-Rico, Diego, Ferreira, Carolina B., Buckland, Karen F., Santilli, Giorgia, Armant, Myriam A., Schambach, Axel, Cavazza, Alessia, Thrasher, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629974/
https://www.ncbi.nlm.nih.gov/pubmed/31338385
http://dx.doi.org/10.1016/j.omtm.2019.05.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629974/
https://www.ncbi.nlm.nih.gov/pubmed/31338385
http://dx.doi.org/10.1016/j.omtm.2019.05.015

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