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Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions

Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in association with pallor, lethargy, and diarrhea, presenting within 1–4 h from the ingestion of a triggering food. In 2017, the international...

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Autores principales: Miceli Sopo, Stefano, Gelsomino, Mariannita, Rivetti, Serena, Del Vescovo, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630359/
https://www.ncbi.nlm.nih.gov/pubmed/31141916
http://dx.doi.org/10.3390/medicina55060216
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author Miceli Sopo, Stefano
Gelsomino, Mariannita
Rivetti, Serena
Del Vescovo, Ester
author_facet Miceli Sopo, Stefano
Gelsomino, Mariannita
Rivetti, Serena
Del Vescovo, Ester
author_sort Miceli Sopo, Stefano
collection PubMed
description Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in association with pallor, lethargy, and diarrhea, presenting within 1–4 h from the ingestion of a triggering food. In 2017, the international consensus guidelines for the diagnosis and management of FPIES were published. They cover all aspects of this syndrome, which in recent decades has attracted the attention of pediatric allergists. In particular, the consensus proposed innovative diagnostic criteria. However, the diagnosis of acute FPIES is still currently discussed because the interest in this disease is relatively recent and, above all, there are no validated panels of diagnostic criteria. We propose some ideas for reflection on the diagnostic and suspicion criteria of acute FPIES with exemplary stories of children certainly or probably suffering from acute FPIES. For example, we believe that new definitions should be produced for mild forms of FPIES, multiple forms, and those with IgE-mediated symptoms. Moreover, we propose two clinical criteria to suspect acute FPIES and to refer the child to the diagnostic oral food challenge.
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spelling pubmed-66303592019-08-19 Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions Miceli Sopo, Stefano Gelsomino, Mariannita Rivetti, Serena Del Vescovo, Ester Medicina (Kaunas) Review Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in association with pallor, lethargy, and diarrhea, presenting within 1–4 h from the ingestion of a triggering food. In 2017, the international consensus guidelines for the diagnosis and management of FPIES were published. They cover all aspects of this syndrome, which in recent decades has attracted the attention of pediatric allergists. In particular, the consensus proposed innovative diagnostic criteria. However, the diagnosis of acute FPIES is still currently discussed because the interest in this disease is relatively recent and, above all, there are no validated panels of diagnostic criteria. We propose some ideas for reflection on the diagnostic and suspicion criteria of acute FPIES with exemplary stories of children certainly or probably suffering from acute FPIES. For example, we believe that new definitions should be produced for mild forms of FPIES, multiple forms, and those with IgE-mediated symptoms. Moreover, we propose two clinical criteria to suspect acute FPIES and to refer the child to the diagnostic oral food challenge. MDPI 2019-05-28 /pmc/articles/PMC6630359/ /pubmed/31141916 http://dx.doi.org/10.3390/medicina55060216 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miceli Sopo, Stefano
Gelsomino, Mariannita
Rivetti, Serena
Del Vescovo, Ester
Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title_full Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title_fullStr Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title_full_unstemmed Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title_short Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions
title_sort food protein-induced enterocolitis syndrome: proposals for new definitions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630359/
https://www.ncbi.nlm.nih.gov/pubmed/31141916
http://dx.doi.org/10.3390/medicina55060216
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