A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated a...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ji, Li, Guotao, Liu, Qihong, Liang, Yan, Liu, Miaochang, Wu, Huayue, Gao, Wenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630543/
https://www.ncbi.nlm.nih.gov/pubmed/31195730
http://dx.doi.org/10.3390/nano9060860
_version_ 1783435326825431040
author Chen, Ji
Li, Guotao
Liu, Qihong
Liang, Yan
Liu, Miaochang
Wu, Huayue
Gao, Wenxia
author_facet Chen, Ji
Li, Guotao
Liu, Qihong
Liang, Yan
Liu, Miaochang
Wu, Huayue
Gao, Wenxia
author_sort Chen, Ji
collection PubMed
description Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.
format Online
Article
Text
id pubmed-6630543
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66305432019-08-19 A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro Chen, Ji Li, Guotao Liu, Qihong Liang, Yan Liu, Miaochang Wu, Huayue Gao, Wenxia Nanomaterials (Basel) Article Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior. MDPI 2019-06-05 /pmc/articles/PMC6630543/ /pubmed/31195730 http://dx.doi.org/10.3390/nano9060860 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Ji
Li, Guotao
Liu, Qihong
Liang, Yan
Liu, Miaochang
Wu, Huayue
Gao, Wenxia
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_full A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_fullStr A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_full_unstemmed A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_short A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_sort photocleavable amphiphilic prodrug self-assembled nanoparticles with effective anticancer activity in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630543/
https://www.ncbi.nlm.nih.gov/pubmed/31195730
http://dx.doi.org/10.3390/nano9060860
work_keys_str_mv AT chenji aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liguotao aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liuqihong aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liangyan aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liumiaochang aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT wuhuayue aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT gaowenxia aphotocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT chenji photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liguotao photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liuqihong photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liangyan photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT liumiaochang photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT wuhuayue photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro
AT gaowenxia photocleavableamphiphilicprodrugselfassemblednanoparticleswitheffectiveanticanceractivityinvitro

Ejemplares similares