Bioengineering an Artificial Human Blood–Brain Barrier in Rodents

Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for ne...

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Detalles Bibliográficos
Autores principales: Kamal, Kimia, Waldau, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630638/
https://www.ncbi.nlm.nih.gov/pubmed/31052208
http://dx.doi.org/10.3390/bioengineering6020038
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author Kamal, Kimia
Waldau, Ben
author_facet Kamal, Kimia
Waldau, Ben
author_sort Kamal, Kimia
collection PubMed
description Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.
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spelling pubmed-66306382019-08-19 Bioengineering an Artificial Human Blood–Brain Barrier in Rodents Kamal, Kimia Waldau, Ben Bioengineering (Basel) Perspective Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling. MDPI 2019-04-30 /pmc/articles/PMC6630638/ /pubmed/31052208 http://dx.doi.org/10.3390/bioengineering6020038 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Kamal, Kimia
Waldau, Ben
Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title_full Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title_fullStr Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title_full_unstemmed Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title_short Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
title_sort bioengineering an artificial human blood–brain barrier in rodents
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630638/
https://www.ncbi.nlm.nih.gov/pubmed/31052208
http://dx.doi.org/10.3390/bioengineering6020038
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