Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Cell-based screening has become the major compound interrogation strategy in Chagas disease drug discovery. Several different cell lines have been deployed as host cells in screening assays. However, host cell characteristics and host-parasite interactions may play an important role when assessing a...

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Detalles Bibliográficos
Autores principales: Franco, Caio Haddad, Alcântara, Laura Maria, Chatelain, Eric, Freitas-Junior, Lucio, Moraes, Carolina Borsoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630705/
https://www.ncbi.nlm.nih.gov/pubmed/31108888
http://dx.doi.org/10.3390/tropicalmed4020082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630705/
https://www.ncbi.nlm.nih.gov/pubmed/31108888
http://dx.doi.org/10.3390/tropicalmed4020082

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