Multi-Color Single-Molecule Imaging Uncovers Extensive Heterogeneity in mRNA Decoding

mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational heterogeneity, we developed the MoonTag, a fluorescence labeling system to visu...

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Detalles Bibliográficos
Autores principales: Boersma, Sanne, Khuperkar, Deepak, Verhagen, Bram M.P., Sonneveld, Stijn, Grimm, Jonathan B., Lavis, Luke D., Tanenbaum, Marvin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630898/
https://www.ncbi.nlm.nih.gov/pubmed/31178119
http://dx.doi.org/10.1016/j.cell.2019.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630898/
https://www.ncbi.nlm.nih.gov/pubmed/31178119
http://dx.doi.org/10.1016/j.cell.2019.05.001

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