Cargando…

Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases

Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the az...

Descripción completa

Detalles Bibliográficos
Autores principales:	Estévez, Juan C., González, Marcos A., Villaverde, M. Carmen, Hirokami, Yuki, Kato, Atsushi, Sussman, Fredy, Reza, David, Estévez, Ramón J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631223/ https://www.ncbi.nlm.nih.gov/pubmed/30934879 http://dx.doi.org/10.3390/ph12020047

Ejemplares similares

Polyhydroxylated Cyclopentane β-Amino Acids Derived from d-Mannose and d-Galactose: Synthesis and Protocol for Incorporation into Peptides
por: Fernández, Fernando, et al.
Publicado: (2022)

The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
por: Shang, Qian, et al.
Publicado: (2013)

Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris
por: Chen, Wei-Hua, et al.
Publicado: (2011)

Polyhydroxylated Nanosized Graphite as Multifunctional Building Block for Polyurethanes
por: Rubino, Lucia, et al.
Publicado: (2022)

Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis
por: Xiang, Limin, et al.
Publicado: (2016)

Synthesis and Antioxidant Activity of Polyhydroxylated trans-Restricted 2-Arylcinnamic Acids
por: Miliovsky, Mitko, et al.
Publicado: (2015)

Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship
por: Song, Xiaoyuan, et al.
Publicado: (2019)

Cytotoxic Polyhydroxylated Oleanane Triterpenoids from Cissampelos pareira var. hirsuta
por: Sun, Yanjun, et al.
Publicado: (2022)

Cytotoxic polyhydroxylated pregnane glycosides from Cissampelos pareira var. hirsuta
por: Sun, Yan-Jun, et al.
Publicado: (2021)

Lysosomes and Lysosomal Storage Diseases
por: Noebels, Jeffrey L.
Publicado: (1981)

Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp
por: Kubota, Takaaki, et al.
Publicado: (2005)

Antibacterial and EGFR-Tyrosine Kinase Inhibitory Activities of Polyhydroxylated Xanthones from Garcinia succifolia
por: Duangsrisai, Susawat, et al.
Publicado: (2014)

Insoluble and Thermostable Polyhydroxyesters From a Renewable Natural Occurring Polyhydroxylated Fatty Acid
por: Benítez, José Jesús, et al.
Publicado: (2019)

Lysosomal storage disorders
por: Cabrera-Salazar, Mario A, et al.
Publicado: (2007)

Lysosomal storage diseases
por: Ferreira, Carlos R., et al.
Publicado: (2017)

Polyhydroxylated fullerene nanoparticles attenuate brain infarction and oxidative stress in rat model of ischemic stroke
por: Vani, Javad Rasouli, et al.
Publicado: (2016)

Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam
por: Kicha, Alla A., et al.
Publicado: (2020)

The use of polyhydroxylated carboxylic acids and lactones to diminish biofilm formation of the pathogenic yeast Candida albicans
por: Ishchuk, Olena P., et al.
Publicado: (2019)

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
por: Platt, Frances M., et al.
Publicado: (2012)

Autophagy in lysosomal storage disorders
por: Lieberman, Andrew P., et al.
Publicado: (2012)

Biomarkers in Lysosomal Storage Diseases
por: Bobillo Lobato, Joaquin, et al.
Publicado: (2016)

Lysosomal Storage Disorders and Malignancy
por: Pastores, Gregory M., et al.
Publicado: (2017)

Polyhydroxylated Steroids from the South China Sea Soft Coral Sarcophyton sp. and Their Cytotoxic and Antiviral Activities
por: Gong, Kai-Kai, et al.
Publicado: (2013)

Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
por: Chen, Min, et al.
Publicado: (2016)

Characterization of sustainable polyhydroxyls, produced from bio-based feedstock, and polyurethane and copolymer urethane-amide foams
por: Stanzione, M., et al.
Publicado: (2018)

Identification and Determination of the Polyhydroxylated Alkaloids Compounds with α-Glucosidase Inhibitor Activity in Mulberry Leaves of Different Origins
por: Ji, Tao, et al.
Publicado: (2016)

When Phosphosugars Meet Gold: Synthesis and Catalytic Activities of Phostones and Polyhydroxylated Phosphonite Au(I) Complexes
por: Malik, Gaëlle, et al.
Publicado: (2015)

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis
por: Napolitano, Gennaro, et al.
Publicado: (2015)

Efficiency in Carbon Dioxide Fixation into Cyclic Carbonates: Operating Bifunctional Polyhydroxylated Pyridinium Organocatalysts in Segmented Flow Conditions
por: Poletti, Lorenzo, et al.
Publicado: (2023)

Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease
por: Blumenreich, Shani, et al.
Publicado: (2020)

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages
por: Aflaki, Elma, et al.
Publicado: (2015)

Lysosomal Storage Diseases—Regulating Neurodegeneration
por: Onyenwoke, Rob U., et al.
Publicado: (2016)

Neuroinflammatory paradigms in lysosomal storage diseases
por: Bosch, Megan E., et al.
Publicado: (2015)

Mitochondrial Dysfunction in Lysosomal Storage Disorders
por: de la Mata, Mario, et al.
Publicado: (2016)

Modeling Lysosomal Storage Diseases in the Zebrafish
por: Zhang, T., et al.
Publicado: (2020)

Therapeutic Approaches in Lysosomal Storage Diseases
por: Fernández-Pereira, Carlos, et al.
Publicado: (2021)

The Role of Exosomes in Lysosomal Storage Disorders
por: Gleason, Adenrele M., et al.
Publicado: (2021)

Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives
por: Kennedy, Andrew, et al.
Publicado: (2005)

Potential Treatment of Lysosomal Storage Disease through Modulation of the Mitochondrial—Lysosomal Axis
por: Kuk, Myeong Uk, et al.
Publicado: (2021)

Branching Off: New Insight Into Lysosomes as Tubular Organelles
por: Bohnert, K. Adam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nk2mvjenacbu5agrf959nl1obf