A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

Background and Objectives: Codeine requires biotransformation by the CYP2D6 enzyme, encoded by the polymorphic CYP2D6 gene, to morphine for therapeutic efficacy. CYP2D6 phenotypes of poor, intermediate, and ultra-rapid metabolisers are at risk of codeine non-response and adverse drug reactions due t...

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Detalles Bibliográficos
Autores principales: Radford, Helen, Simpson, Karen H., Rogerson, Suzanne, Johnson, Mark I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631257/
https://www.ncbi.nlm.nih.gov/pubmed/31141989
http://dx.doi.org/10.3390/medicina55060220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631257/
https://www.ncbi.nlm.nih.gov/pubmed/31141989
http://dx.doi.org/10.3390/medicina55060220

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