QbD Based Media Development for the Production of Fab Fragments in E. coli

Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, Escherichia coli. However, low expression levels result in a high manufacturing cost. The protein expression can be in...

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Detalles Bibliográficos
Autores principales: Kumar, Deepak, Batra, Jyoti, Komives, Claire, Rathore, Anurag S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631317/
https://www.ncbi.nlm.nih.gov/pubmed/30925730
http://dx.doi.org/10.3390/bioengineering6020029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631317/
https://www.ncbi.nlm.nih.gov/pubmed/30925730
http://dx.doi.org/10.3390/bioengineering6020029

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