Tegsedi (Inotersen): An Antisense Oligonucleotide Approved for the Treatment of Adult Patients with Hereditary Transthyretin Amyloidosis

Tegsedi (Inotersen) is a chemically modified antisense oligonucleotide that inhibits the hepatic production of transthyretin (TTR). Several single-point mutations in TTR destabilize its structure, leading to the aggregation and accumulation of amyloid deposits in the nervous system, heart, kidneys a...

Descripción completa

Detalles Bibliográficos
Autor principal: Gales, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631675/
https://www.ncbi.nlm.nih.gov/pubmed/31117178
http://dx.doi.org/10.3390/ph12020078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631675/
https://www.ncbi.nlm.nih.gov/pubmed/31117178
http://dx.doi.org/10.3390/ph12020078

Ejemplares similares